Supermolecules for Self-Assembled Medicine – Super-SAM

Medway Research Seminars 2017-18
Wednesday 31st January 2018, 13.00 - 14.00
Jellicoe Building Room J106

 

Prof. David K. Smith


Department of Chemistry, University of York

Soft matter systems, self-assembled from molecular-scale building blocks, offer a powerful strategy by which we can program and control the nanoworld, from the bottom up[1]. We will discuss the self-assembly of soft nanomaterials, and in particular come to an understanding of how we can interface them with pharmaceutical and biological systems. This leads to a range of ways in which non-covalent interactions can be used to underpin potential new medicinal applications. We will explore self-assembled nanosystems capable of:

  • DNA binding (for gene therapy applications)[2]
  • Heparin binding (for coagulation control applications)[3]
  • Non-Steroidal Anti-Inflammatory Drug binding (for pain relief applications)[4]
  • Cellular interactions (for tissue engineering applications)[5]

In this way, we will gain useful insights into how a supramolecular approach may allow us to achieve ‘medicine beyond the molecule’.

References: [1] Chem. Soc. Rev. 2017, 46, 2404. [2] (a) J. Am. Chem. Soc. 2011, 133, 20288 (b) J. Mater. Chem. B 2014, 2, 2153. [3] Chem. Sci. 2014, 5, 1484. [4] (a) Chem. Commun. 2015, 51, 7451. (b) Chem. Sci. 2017, 8, 7218. [5] (a) Angew. Chem. Int. Ed. 2014, 53, 12461. (b) J. Am. Chem. Soc. 2015, 137, 15486. (c) Chem. Sci. 2017, 8, 6981.

Dave Smith is Professor of Chemistry at University of York, where he carries out fundamental research into smart nanomaterials and nanomedicines, publishing ca. 150 research papers, and with an hindex > 50. He is a passionate educator, giving outreach lectures to ca. 50,000 UK school students and developing his own YouTube chemistry channel, with over half a million views. Dave has been recognised for excellence both in research and teaching, having received the Corday Morgan Award from The Royal Society of Chemistry and a National Teaching Fellowship from the Higher Education Academy. He was nominated as one of the RSC’s 175 diverse ‘Faces of Chemistry’. Dave entered into a civil partnership with his husband Sam in 2010. They live in central York, with their adopted son, where they enjoy the vibrant and historic city, and like cooking and travelling.

Tel: +44 (0) 1634 202935
Fax: +44 (0) 1634 883927

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Last Updated 25/01/2018