Supermolecules for Self-Assembled Medicine – Super-SAM
Medway Research Seminars 2017-18
Wednesday 31st January 2018, 13.00 - 14.00
Jellicoe Building Room J106
Prof. David K. Smith
Department of Chemistry, University of York
Soft matter systems, self-assembled from molecular-scale building blocks, offer a powerful strategy by which we can program and control the nanoworld, from the bottom up. We will discuss the self-assembly of soft nanomaterials, and in particular come to an understanding of how we can interface them with pharmaceutical and biological systems. This leads to a range of ways in which non-covalent interactions can be used to underpin potential new medicinal applications. We will explore self-assembled nanosystems capable of:
- DNA binding (for gene therapy applications)
- Heparin binding (for coagulation control applications)
- Non-Steroidal Anti-Inflammatory Drug binding (for pain relief applications)
- Cellular interactions (for tissue engineering applications)
In this way, we will gain useful insights into how a supramolecular approach may allow us to achieve ‘medicine beyond the molecule’.
References:  Chem. Soc. Rev. 2017, 46, 2404.  (a) J. Am. Chem. Soc. 2011, 133, 20288 (b) J. Mater. Chem. B 2014, 2, 2153.  Chem. Sci. 2014, 5, 1484.  (a) Chem. Commun. 2015, 51, 7451. (b) Chem. Sci. 2017, 8, 7218.  (a) Angew. Chem. Int. Ed. 2014, 53, 12461. (b) J. Am. Chem. Soc. 2015, 137, 15486. (c) Chem. Sci. 2017, 8, 6981.
Dave Smith is Professor of Chemistry at University of York, where he carries out fundamental research into smart nanomaterials and nanomedicines, publishing ca. 150 research papers, and with an hindex > 50. He is a passionate educator, giving outreach lectures to ca. 50,000 UK school students and developing his own YouTube chemistry channel, with over half a million views. Dave has been recognised for excellence both in research and teaching, having received the Corday Morgan Award from The Royal Society of Chemistry and a National Teaching Fellowship from the Higher Education Academy. He was nominated as one of the RSC’s 175 diverse ‘Faces of Chemistry’. Dave entered into a civil partnership with his husband Sam in 2010. They live in central York, with their adopted son, where they enjoy the vibrant and historic city, and like cooking and travelling.