Svetlana Sakhnevych Svetlana Sakhnevych
Research area: Biological Sciences group, Infectious Diseases and Allergy
Supervisors: Dr Vadim Sumbayev, Prof Yuri Ushkaryov

Research title: Cell-surface receptors latrophilins 1, 2 and 3 and Tim-3 as novel myeloid leukaemia biomarkers and therapeutic targets

The aim of the project is to study the role of latrophilins (LPHNs) and Tim-3 in in human acute myeloid leukaemia (AML) progression and their potential use as therapeutic targets. Indeed, it was discovered that LPHNs 1 and 3 are expressed in human AML cells, but not in healthy leukocytes. The immune-cell receptor Tim-3 is also highly expressed on the surface of AML cells compared to healthy leukocytes.

Stimulation of LPHN1 or Tim-3 by respective ligands triggers intracellular calcium signalling and potentiates cellular responses to inflammatory mediators (Toll-like receptor ligands), which leads to exocytosis of cytokines and angiogenic growth factors and AML progression.

Thus both receptors may be used as potential AML biomarkers and drug delivery targets.

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Last Updated 17/10/2016