|Research area: Biological Sciences group, Infectious Diseases and Allergy|
|Supervisors: Dr Vadim Sumbayev, Prof Yuri Ushkaryov|
Research title: Cell-surface receptors latrophilins 1, 2 and 3 and Tim-3 as novel myeloid leukaemia biomarkers and therapeutic targets
The aim of the project is to study the role of latrophilins (LPHNs) and Tim-3 in in human acute myeloid leukaemia (AML) progression and their potential use as therapeutic targets. Indeed, it was discovered that LPHNs 1 and 3 are expressed in human AML cells, but not in healthy leukocytes. The immune-cell receptor Tim-3 is also highly expressed on the surface of AML cells compared to healthy leukocytes.
Stimulation of LPHN1 or Tim-3 by respective ligands triggers intracellular calcium signalling and potentiates cellular responses to inflammatory mediators (Toll-like receptor ligands), which leads to exocytosis of cytokines and angiogenic growth factors and AML progression.
Thus both receptors may be used as potential AML biomarkers and drug delivery targets.