Dr Gurprit S. Lall
Senior Lecturer in Pharmacology / Neurophysiology
Dr Gurprit Lall completed his undergraduate degree in Physiology at the university of Dundee in 1999. He obtained his MSc in Neuroscience from the Institute of Psychiatry, Kings College London in 2000. Following this, Gurprit completed his PhD at the University of Glasgow in 2003. His PhD thesis focused on the interactions between Neuropeptide Y and light in the regulation of the master circadian pacemaker. His post-doctoral research has focused on looking at the influences of serotonin on the circadian clock (Smith College, MA, USA) and more recently focusing on retinal physiology and assessing the contributions of photoreceptors in the mediation of non-image forming responses to light (University of Manchester, UK). Currently, he holds a position at the Medway School of Pharmacy as a lecturer in Pharmacology/ Neurophysiology and serves as a member of the NANOVAC consortium Specialist areas Circadian Neurobiology, Biological rhythms. Currently course co-ordinator for first year Body Systems module.
Dr Lall's research interests lie within biological rhythms and circadian neurobiology. He is particularly interested in the way in which the mammalian circadian clock, located in the brain, responds to environmental stimuli such as light and non-photic cues which include exercise and feeding. My most recent studies have looked at the neural basis of circadian entrainment and retinal photoreceptor contribution to non-image forming circadian responses. Disruptions of this type of biological rhythm have been shown to result in, amongst others, states of depression, seasonal effective disorder (S.A.D.) and, most recently, the onset of cancer in humans. Current Projects Current research projects focus on how light driven responses are interpreted by the retina and circadian clock, from a mechanistic point of view and with regards to possible changes that occur during ageing. Recent publications Bonsall DR and Lall GS, Protein Kinase C differentially regulates entrainment of the mammalian circadian clock. Chronobiology International, in press. Lall GS, Atkinson LA, Corlett SA, Broadbridge PJ, Bonsall DR (2012) Circadian entrainment and its role in depression: a mechanistic review. J Neural Transm 119:1085-1096. Lucas RJ, Lall GS, Allen AE, Brown TM (2012) How rod, cone, and melanopsin photoreceptors come together to enlighten the mammalian circadian clock. Prog Brain Res 199:1-18. Sumbayev VV, Yasinska IM, Garcia CP, Gilliland D, Lall GS, Gibbs BF, Bonsall DR, Varani L, Rossi F, Calzolai L. Gold nanoparticles downregulate interleukin-1β-induced pro-inflammatory responses. Small, in press. Nicholas SA, Coughlan K, Yasinska I, Lall GS, Gibbs BF, Calzolai L, Sumbayev VV (2011) Dysfunctional mitochondria contain endogenous high-affinity human Toll-like receptor 4 (TLR4) ligands and induce TLR4-mediated inflammatory reactions. Int J Biochem Cell Biol 43:674-681. Lall GS, Revell VL, Momiji H, Al Enezi, Atimus OM, Guler AS, Aguilar C, Cameron MA, Allender S, Hankins MW, Lucas RJ (2010) Distinct contributions of Rod, Cone melanopsin photoreceptors to encoding erradiance. Neuron 66:417-428. Full list of publications Guler AD*, Ecker JL*, Lall GS*, Haq S, Altimus CM, Liao HW, Barnard AR, Cahill H, Badea TC,Zhao H, Hankins MW, Berson DM, Lucas RJ, Yau KW, Hattar S (2008) Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature 453:102-105. *equal contributing first author. Sakaran, S., Lall, G.S., Lucas, R.J., Foster, R. and Hankins, M., (2007). 2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo. Journal of Neuroscience. 27 (15): 3981-3986. Harrington, M., Molyneux, P., Soscia. S., Prabakar. C., McKinley-Brewer, J., Lall, G.S., (2007) Behavioral and neurochemical sources of variability of circadian period and phase: studies of circadian rhythms of npy-/- mice. American Journal of Physiology. Regulatory, integrative and comparative physiology. 292(3): R1306-R1314. Lall, G.S. and Harrington, M.E.,(2006). Potentiation of the resetting effects of light on circadian rhythms of hamsters using serotonin and NPY receptor antagonistsNeuroscience. 141, 1545-52. Lall, G. S. and Biello, S.M., (2003). Neuropeptide Y, GABA and circadian phase shifts to photic stimuli. Neuroscience. 120, 915-921. Lall, G. S. and Biello, S. M., (2003). Attenuation of circadian light induced phase advances and delays by neuropeptide Y and a neuropeptide Y Y1/Y5 receptor agonist. Neuroscience. 119, 625-631. Lall, G. S. and Biello, S. M., (2002). Attenuation of phase shifts to light by activity or neuropeptide Y: a time course study. Brain Research. 957, 109-116.