Medway school of pharmacy

12/ 2006 - present  

Lecturer in Biochemistry, Medway School of Pharmacy, University of Kent

12/2003 - 11/2006  

Assistant Professor, University of Aarhus, Department of Molecular Biology, iNANO Center

7/ 2003–11/2003

Research Fellow, University of Kaiserslautern, Institute for Cell Biology

1/2003 - 6/2003

Associate Professor, Mechnikov Odessa University, Department of Biochemistry

11/2001-12/2002  

Humboldt Research Fellow, University of Kaiserslautern, Institute  for Cell Biology

9/1999 - 10/2001 

Assistant, then Associate Professor, Mechnikov Odessa University, Department of Biochemistry

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Our research is focused on the signalling mechanisms involved in inflammatory/innate immune responses. We are currently interested in cross-talk of MAP kinase-dependent apoptotic pathway and hypoxic signal transduction in toll-like receptor signalling. We also study the role/cross-talk of both pathways in programmed cell death. Furthermore we are investigating biochemical mechanisms involved in regulation of toll-like receptor signalling and cell growth by oestrogens and environmental endocrine disruptors interfering with oestrogen action.

Our new area of interest is the molecular mechanisms of interference of Nef and Tat proteins of human immunodeficiency virus 1 (HIV-1) with apoptotic/hypoxic signalling pathways in infected and bystander cells.

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• Casely-Hayford, M. A., Nicholas, S. A., and Sumbayev, V. V. (2009) Azinomycin epoxide induces activation of apoptosis signal-regulating kinase 1 (ASK1) and caspase 3 in a HIF-1-independent manner in human leukaemia myeloid macrophages. Eur. J. Pharmacol. 602: 262-269.
• Lall H., Coughlan, K. and Sumbayev V. V. (2008) HIF-1 protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6. Mol. Immunol. 45: 3045-3049.
• Sumbayev V. V. (2008) LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein. FEBS Lett. 582: 319-326.
• Sumbayev, V. V., Jensen, J. K., Hansen, J. A., Andreasen, P. A. (2008) Novel modes of oestrogen receptor agonism and antagonism by hydroxylated and chlorinated biphenyls, revealed by conformation-specific peptide recognition patterns. Mol. Cell. Endocrinol. 287: 30-39.
• Sumbayev, V. V., Yasinska, I. M. (2008) Protein S-nitrosation in signal transduction. Assays for specific qualitative and quantitative analysis. Meth. Enzymol. 440: 209-219.
• Jawahir, M. B., Nicholas, S. A., Coughlan, K. and Sumbayev, V. V. (2008) Apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein are essential factors for nitric oxide-dependent accumulation of p53 in THP-1 human myeloid macrophages. Apoptosis 13: 1410-1416.
• Sumbayev V. V. (2008) PI3 kinase and direct S-nitrosation are involved in down-regulation of apoptosis signal-regulating kinase 1 during LPS-induced Toll-like receptor 4 signalling. Immunol. Lett. 115: 126-130.
• Hansen, J. A., Sumbayev, V. V., Gothelf, K. V. (2007) An electrochemical sensor based on the human estrogen receptor ligand binding domain. NANO Lett. 7: 2831-2834.
• Sumbayev, V. V., Yasinska, I. M. (2007) Mechanisms of hypoxic signal transduction regulated by reactive nitrogen species Scand. J. Immunol. 65: 399-406.

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