Medway school of pharmacy

Ruey-Leng graduated from the University of Bradford and completed her pre-registration training at the GlaxoWellcome (currently known as GlaxoSmithKline) and Southend General Hospital. Once qualified, she worked as a hospital pharmacist for several years before she decided to undertake a PhD in Biological Chemistry at the Imperial College London. Upon completion of her PhD, she held a postdoctoral research position there for a year. Her research has focused on the application of metabolic profiling methods (metabonomics) to a large-scale international epidemiological study based on multivariate statistical method development and implementation.

She is a Visiting Lecturer in the Department of Surgery and Cancer at Imperial College.

Awards

Medical Research Council New Investigator Grant Award (2011) 1 Oct 2011 - 30 Sep 2014

Memberships of Professional Bodies

Associate Member (AMRSC), Royal Society of Chemistry. 2005 -

General Pharmaceutical Council. 2010 -

back to top

Ruey-Leng's main research focus is on the characterisation of the human metabolome using NMR and chemometric modeling techniques (metabonomics) to further understand the potential biological mechanisms that trigger diseases. The application of her research has been focused on hypertension and obesity but has recently investigated the impact of various environmental toxins and xenobiotics on human health. The metabolisms of various xenobiotics/environmental toxins are also explored in relation to different genotypes/phenotypes. She is also interested in the concept of personalised health care.

External collaborations

Johns Hopkins University, Prof. Lawrence Appel and Prof. Frederick L Brancati 2010 -

Imperial College London, Prof. Elaine Holmes and Prof. Jeremy K Nicholson 2004 -

back to top

• Loo RL, Chan Q, Brown IJ, Robertson CE, Stamler J, Nicholson JK, Holmes E, Elliott P.  A Comparison of Self-Reported Analgesic Use and Detection of Urinary Ibuprofen and Acetaminophen Metabolites by Means of Metabonomics: The INTERMAP Study.  Am J Epidemiol. In press
• Yap IKS; Brown IJ; Chan Q; Wijeyesekera A; Garcia-Perez I; Bictash M; Loo RL; Marc Chadeau-Hyam , Timothy Ebbels , Maria De Iorio , Elaine Maibaum , Liancheng Zhao , Hugo Kesteloot , Martha L Daviglus , Jeremiah Stamler , Jeremy Kirk Nicholson , Paul Elliott , Elaine Holmes. (2010). Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP Study. J. Proteome Res. 9: 6647-6654
• Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IK, Brown IJ, de Iorio M, Daviglus ML, Holmes E, Stamler J, Nicholson JK, Elliott P. (2010). Opening up the "Black Box": Metabolic phenotyping and metabolome-wide association studies in epidemiology. J Clin Epidemiol. 63: 970-979
• Loo RL, Coen M, Ebbels T, Cloarec O, Maibaum E, Bictash M, Yap I, Elliott P, Stamler J, Nicholson JK, Holmes E. (2009) Metabolic Profiling and Population Screening of Analgesic Usage in NMR-Spectroscopy-based Large-scale Epidemiologic Studies. Anal Chem. 81:5119-29.
• Holmes E*, Loo RL*, Stamler J, Bictash M, Yap IK, Chan Q, Ebbels T, De Iorio M, Brown IJ, Veselkov KA, Daviglus ML, Kesteloot H, Ueshima H, Zhao L, Nicholson JK, Elliott P. (2008) Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 453, 396-400 (*Joint first authorship).
• Holmes E*, Loo RL*, Cloarec O, Coen M, Tang H, Maibaum E, Bruce S, Chan Q, Elliott P, Stamler J, Wilson ID, Lindon JC, Nicholson JK. (2007) Detection of Urinary Drug Metabolite (Xenometabolome) Signatures in Molecular Epidemiology Studies via Statistical Total Correlation (NMR) Spectroscopy. Anal Chem. 79:2629-40 (*Joint first authorship).

back to top