Dr Ruey-Leng Loo

BPharm(Hons), PhD, AMRSC, MRPharmS

Clinical Lecturer in Pharmacy Practice

Phone: +44 (0)1634 20 2948
Email: R.Loo@kent.ac.uk

Ruey-Leng graduated from the University of Bradford and completed her pre-registration training at the GlaxoWellcome (currently known as GlaxoSmithKline) and Southend General Hospital. Once qualified, she worked as a hospital pharmacist for several years before she decided to undertake a PhD in Biological Chemistry at the Imperial College London. Upon completion of her PhD, she held a postdoctoral research position there for a year. Her research has focused on the application of metabolic profiling methods (metabonomics) to a large-scale international epidemiological study based on multivariate statistical method development and implementation. Ruey-Leng joined the Medway School of Pharmacy in September 2009.

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Ruey-Leng’s main research focus is on the characterisation of the human metabolome using NMR and chemometric modeling techniques (metabonomics) to further understand the potential biological mechanisms that trigger diseases. The application of her research has been focused on hypertension and obesity but has recently investigated the impact of various environmental toxins and xenobiotics on human health. The metabolisms of various xenobiotics/environmental toxins are also explored in relation to different genotypes/phenotypes. She is also interested in the concept of personalised health care.

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  • Loo RL, Coen M, Ebbels T, Cloarec O, Maibaum E, Bictash M, Yap I, Elliott P, Stamler J, Nicholson JK, Holmes E (2009) Metabolic Profiling and Population Screening of Analgesic Usage in NMR-Spectroscopy-based Large-scale Epidemiologic Studies. Anal Chem. 81, 5119-29.
  • Holmes E*, Loo RL*, Stamler J, Bictash M, Yap IK, Chan Q, Ebbels T, De Iorio M, Brown IJ, Veselkov KA, Daviglus ML, Kesteloot H, Ueshima H, Zhao L, Nicholson JK, Elliott P (2008) Human metabolic phenotype diversity and its association with diet and blood pressure. Nature, 453, 396-400. *equal contributing first author.
  • Holmes E*, Loo RL*, Cloarec O, Coen M, Tang H, Maibaum E, Bruce S, Chan Q, Elliott P, Stamler J, Wilson ID, Lindon JC, Nicholson JK (2007) Detection of Urinary Drug Metabolite (Xenometabolome) Signatures in Molecular Epidemiology Studies via Statistical Total Correlation (NMR) Spectroscopy. Anal Chem., 79, 2629-40. *equal contributing first author.

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