describe image here Emma L Veale

BSc(Hons) in Biochemistry

Research Associate

Phone: +44 (0)1634 20 2960
Email: E.L.Veale@kent.ac.uk

I studied biochemistry at the University of Brunel, graduating in 1996. Following my degree I took a position as a research technician at Imperial College London, working initially in plant research, with the late Dr Gary Warren. I then became a research assistant, working for Professor Brian Robertson and Professor Alistair Mathie studying ion channels in neurons. In May 2007, I moved with Professor Mathie to take up my current position as a research associate in the biological sciences group within the Medway school of Pharmacy.

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My research interests include the function and regulation of neuronal potassium channels.

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  • Veale EL, Rees KA, Mathie A, Trapp S (2010). Dominant negative effects of a non-functional TREK1 splice variant expressed in brain. J Biol Chem 285: 29295-29304.
  • Mathie A, Al Moubarak E, Veale EL (2010). Gating of two pore domain potassium channels. J Physiol 588: 3149-3156.
  • Mathie A, Rees KA, El Hachmane MF, Veale EL (2010). Trafficking of neuronal two pore domain potassium channels. Curr Neuropharmacol 8: 276-286.
  • Cao L, Veale EL, Mathie A, Stevens E (2010). Differential modulation of TREK-1, TASK-3 and TRESK K2P ion channels by BL-1249. Program No. 174.6/KK13. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online.
  • Rees KA, Veale EL, Mathie A (2010). Stimulation of heteromeric TASK channel trafficking by 14-3-3(beta) protein. Basic and Clinical Pharmacology & Toxicology 107 (Suppl. 1), 119.
  • Clarke CE, Veale EL*, Wyse K, Vandenberg JI, Mathie A (2008). The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function. J Biol Chem 283: 16985-16992. * joint first author.
  • Mathie A, Veale EL (2008). Neuronal Potassium Channels. In Encyclopedia of Neuroscience: 2792-2797. eds. Binder M, Hirokawa N, Windhorst U, Hirsch MC, Springer-Verlag (Berlin).
  • Veale EL, Aller MI, Mathie A (2008). Functional characteristics and regulation of mouse THIK1 two-pore-domain potassium channels. Acta Physiol Sinica 60 S1: 229.
  • Veale EL, Buswell R, Clarke CE, Mathie A (2007). Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide. Br J Pharmacol 152: 778-786.
  • Brickley SG, Aller MI, Sandu C, Veale EL, Alder FG, Sambi H, Mathie A, Wisden W (2007). TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons. J Neurosci 27: 9329-9340.
  • Mathie A, Veale EL (2007). Therapeutic potential of neuronal two pore domain potassium channel modulators. Curr Opin Invest Drugs 8: 555-562.
  • Veale EL, Kennard LE, Sutton GL, MacKenzie G, Sandu C, Mathie A (2007). G(alpha)q mediated regulation of TASK3 two pore domain potassium channels: the role of protein kinase C. Mol Pharmacol 71: 1666-1675.
  • Veale EL, Buswell R, Clarke CE, Mathie A (2007). Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide. Brit J Pharmacol advanced online publication doi:10.1038/sj.bjp.0707436.
  • Brickley SG, Aller MI, Sandu C, Veale EL, Alder FG, Sambi H, Mathie A, Wisden W (2007).  TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons. J Neurosci 27:9329-9340.
  • Mathie A, Veale EL (2007).  Therapeutic potential of neuronal two-pore domain potassium-channel modulators. Curr Opin Investig Drugs 8:555-562.
  • Veale EL, Kennard LE, Sutton GL, MacKenzie G, Sandu C, Mathie A (2007).  G(alpha)q-mediated regulation of TASK3 two-pore domain potassium channels: the role of protein kinase C. Mol Pharmacol 71:1666-1675.
  • Mathie A, Sutton GL, Clarke CE, Veale EL (2006).  Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther 111:567-583.
  • Linden AM, Aller MI, Leppa E, Vekovischeva O, Aitta-Aho T, Veale EL, Mathie A, Rosenberg P, Wisden W, Korpi ER (2006). The contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists. J Pharmacol Exp Ther 317:615-626.
  • Aller MI, Veale EL, Linden AM, Sandu C, Schwaninger M, Evans LJ, Korpi ER, Mathie A, Wisden W, Brickley SG (2005). Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons. J Neurosci 25:11455-11467.
  • Kennard LE, Chumbley JR, Ranatunga KM, Armstrong SJ, Veale EL, Mathie A (2005). Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine. Br J Pharmacol 144:821-829.
  • Clarke CE, Veale EL, Green PJ, Meadows HJ, Mathie A (2004). Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc. J Physiol 560:51-62.
  • Mathie A, Clarke CE, Ranatunga KM, Veale EL (2003). What are the roles of the many different types of potassium channel expressed in cerebellar granule cells? Cerebellum 2:11-25.

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