Medway school of pharmacy

Andy obtained his BSc (Hons) in Applied Chemistry from the University of Aston in 1990 and received his PhD (Chemistry) from the same institution in 1995. He then held post-doctoral research positions at the University of Strathclyde (1994-1996) and the University of Manchester (1996-1999), before moving to the Johannes Gutenberg University of Mainz, Germany to take up an EU-TMR fellowship. After three years in Mainz, Andy moved to the Institute for Environmental Research at the University of Dortmund, Germany, again as a research fellow. In 2006, Andy was appointed to his first academic position as Senior Lecturer in Chemistry at the Sunderland Pharmacy School.

Andy took up his current position as Senior Lecturer in Chemistry & Drug Delivery in September 2009.

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Andy’s research interests lie in the realms of molecular recognition (supramolecular chemistry) and polymer chemistry. Of particular interest is the marriage of these two areas for the synthesis of macromolecular receptors via the technique of molecular imprinting.

Molecularly imprinted polymers (MIPs) are an example of template-synthesised materials, which differ from this general class in that removal of the template leaves behind cavities that are complementary to the template in terms of size, shape and functionality. MIPs have been proposed for use in many application areas, e.g. selective separations, sensing, drug discovery, targeted drug delivery and enzyme-like catalysis. Current research interests include:

• the design and synthesis of improved functional and cross-linking monomers
• the preparation of MIPs in a variety of two- and three-dimensional formats
• preparation of multifunctional MIPs
• thermodynamic mechanisms for MIP formation
• study of the mechanisms leading to imprinted binding site formation

Target substances include organo-pollutants (including active pharmaceutical ingredients and their metabolites, herbicides and pesticides) and biomarkers for a variety of disease states.

Further, related areas of interest concern:

• the design of monomeric and polymer-supported organo-catalysts
• the design and synthesis of supramolecular polymers

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• Emgenbroich, M, Borrelli, C, Shinde, S, Lazraq, I, Vilela, F, Hall, AJ, Oxelbark, J, De Lorenzi, E, Courtois, J, Simanova, A, Verhage, J, Irgum, K, Karim, K, Sellergren, B (2008). A phosphotyrosine-imprinted polymer receptor for the recognition of tyrosine phosphorylated peptides. Chemistry - A European Journal, 14, 9516-9529.
• Kamau SD, Hodge P, Hall AJ, Dad S and Ben-Haida A (2007).
  Cyclo-depolymerization of olefin-containing polymers to give macrocyclic oligomers by metathesis and the entropically-driven ROMP of the olefin-containing macrocyclic esters. Polymer, 48, 6808-6822.
• Urraca JL, Moreno-Bondi MC, Orellana G, Sellergren B and Hall AJ (2007).
  Molecularly imprinted polymers as antibody mimics in automated on-line fluorescent competitive assays. Analytical Chemistry, 79, 4915-4923.
• Urraca JL, Moreno-Bondi MC, Hall AJ, and Sellergren B (2007).
  Direct Extraction of Penicillin G and Derivatives from Aqueous Samples using a Stoichiometrically Imprinted Polymer. Analytical Chemistry, 79, 695-701.
• Skogsberg U, Meyer C, Rehbein J, Fischer G, Schauff S, Welsch N, Albert K, Hall AJ and Sellergren B (2007). A Solid-State and Suspended-State Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopic Investigation of a 9-Ethyladenine Molecularly Imprinted Polymer Polymer, 48, 229-238.
• Hall AJ, Quaglia M, Manesiotis P, Achilli L, De Lorenzi E and Sellergren B (2006).
  Polymeric Receptors for the Recognition of Folic Acid and Related Compounds via Substructure Imprinting (IV). Analytical Chemistry, 78, 8362–8367.
• Hall A, Hodge P, Kamau SD and Ben-Haida A (2006).
  Acyclic Diene Metathesis (ADMET) Polymerization of Allyl Undec-10-enoate and Some Related Esters. Journal of Organometallic Chemistry, 691, 5431–5437.
• Urraca JL, Hall AJ, Moreno-Bondi MC and Sellergren B (2006).
  A Stoichiometric Molecularly Imprinted Polymer for the Class-Selective Recognition of Antibiotics in Aqueous Media. Angewandte Chemie, 118, 5282-5285; Angew. Chem., Int. Ed. Engl., 45, 5158-5161.
• Manesiotis P, Hall AJ, Courtois J, Irgum K and Sellergren B (2005).
  An Artificial Riboflavin Receptor Prepared via a Template Analogue Imprinting Strategy. Angewandte Chemie, 117, 3970-3974; Angew. Chem., Int. Ed. Engl., 2005, 44, 3902-3906.
• Hall AJ, Lanza-Sellergren F, Manesiotis P and Sellergren B (2005).
  Non-Covalent Imprinting of Phosphorous Esters. Analytica Chimica Acta, 538 (1-2), 9-14.
• Manesiotis P, Hall AJ and Sellergren B (2005).
  Improved Receptors for Imides Based on Novel Fluorescent Donor-Acceptor-Donor Reporter Monomers. Journal of Organic Chemistry, 70, 2729-2738.
• Hall AJ, Manesiotis P, Emgenbroich M, Quaglia M, De Lorenzi E and Sellergren B (2005). Urea Host Monomers for Stoichiometric Molecular Imprinting of Oxyanions”
  Journal of Organic Chemistry, 70, 1732-1736.
• Manesiotis P, Hall AJ, Emgenbroich M, Quaglia M, De Lorenzi E and Sellergren B (2004). An Enantioselective Imprinted Receptor for Z-glutamate Exhibiting a Binding Induced Color Change. Chemical Communications, 2278-2279.

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